Article
Increased expression of B cell activation factor supports the abnormal expansion of transitional B cells in systemic lupus erythematosus.
The Journal of rheumatology - 1 Apr 2011
Landolt-Marticorena Carolina, Wither Robert, Reich Heather, Herzenberg Andrew, Scholey James, Gladman Dafna D, Urowitz Murray B, Fortin Paul R, Wither Joan
Abstract excerpt
OBJECTIVE: To examine the relationship between interferon-α (IFN-α) and dysregulation of B cell activation factor (BAFF) and specific B cell phenotypes in systemic lupus erythematosus (SLE). METHODS: Four-color flow cytometry was used to examine the peripheral B cell populations in patients with SLE. RNA was isolated from the peripheral blood of 87 patients and BAFF expression was determined by quantitative...
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