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Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood

17 Mar 2003

Abstract excerpt

Systemic lupus erythematosus (SLE) is a prototype systemic autoimmune disease characterized by flares of high morbidity. Using oligonucleotide microarrays, we now show that active SLE can be distinguished by a remarkably homogeneous gene expression pattern with overexpression of granulopoiesis-related and interferon (IFN)-induced genes. Using the most stringent statistical analysis (Bonferroni correction), 15...

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PMID: 12642603
DOI: 10.1084/jem.20021553

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