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Article

Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter.

Nature communications - 19 Apr 2016

Rannversson Hafsteinn, Andersen Jacob, Sørensen Lena, Bang-Andersen Benny, Park Minyoung, Huber Thomas, Sakmar Thomas P, Strømgaard Kristian

Abstract excerpt

Despite the well-established role of the human serotonin transporter (hSERT) in the treatment of depression, the molecular details of antidepressant drug binding are still not fully understood. Here we utilize amber codon suppression in a membrane-bound transporter protein to encode photocrosslinking unnatural amino acids (UAAs) into 75 different positions in hSERT. UAAs are incorporated with high specificity,...

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Identifiers

PMID: 27089947
DOI: 10.1038/ncomms11261
PMCID: PMC4838859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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