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Inhibition of Soluble Epoxide Hydrolase Confers Neuroprotection and Restores Microglial Homeostasis in a Tauopathy Mouse Model

2025-02-24

Abstract excerpt

<title>Abstract</title> <p>Background: The epoxyeicosatrienoic acids (EETs) are derivatives of the arachidonic acid metabolism with anti-inflammatory activities. However, their efficacy is limited due to the rapid hydrolysis by the soluble epoxide hydrolase (sEH). Accordingly, inhibition of sEH has been shown to stabilize the EETs and dampen neuroinflammation in Ab mouse models of Alzheimer’s disease (AD). Howeve...

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Literature Corpus work
273a5f5f-3131-597d-8d40-25ddbb0c83c0
DOI
10.21203/rs.3.rs-6038641/v1
Open publication

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Inhibition of Soluble Epoxide Hydrolase Confers Neuroprotection and Restores Microglial Homeostasis in a Tauopathy Mouse ModelDOI 10.21203/rs.3.rs-6038641/v1
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