Article

Single-cell transcriptomics uncovers chromatin dysfunction in a human TDP-43 proteinopathy model of Amyotrophic Lateral Sclerosis

2026-05-13

Abstract excerpt

TDP-43 proteinopathy, characterised by nuclear depletion and cytoplasmic aggregation of TDP-43, is the defining pathological hallmark of amyotrophic lateral sclerosis (ALS) and a shared pathology across frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP), limbic-predominant age-related TDP-43 encephalopathy (LATE), and a substantial subset of Alzheimer’s disease. We recently developed a human model...

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Literature Corpus work: 79b5f392-84a9-59f7-bbbb-c547ca32b414
DOI: 10.64898/2026.05.10.724071

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