Article

TAD hierarchy restricts poised LTR activation and loss of TAD hierarchy promotes LTR co-option in cancer

2024-06-06

Abstract excerpt

Transposable elements (TEs) are abundant in the human genome, and they provide the sources for genetic and functional diversity. The regulation of TEs expression and their functional consequences in physiological conditions and cancer development remain to be fully elucidated. Previous studies suggested TEs are repressed by DNA methylation and chromatin modifications. The effect of 3D chromatin topology on TE regu...

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Literature Corpus work: 112849d5-4646-559a-b34e-ba88f5825a6c
DOI: 10.1101/2024.05.31.596845

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