Article

Glucose-dependent miR-125b is a negative regulator of β-cell function

2021-05-17

Abstract excerpt

<h4>ABSTRACT</h4> Impaired pancreatic β-cell function and insulin secretion are hallmarks of type 2 diabetes. MicroRNAs are short non-coding RNAs that silence gene expression, vital for the development and function of β-cells. We have previously shown that β-cell specific deletion of the important energy sensor AMP-activated protein kinase (AMPK) results in increased miR-125b-5p levels. Nevertheless, the function...

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Literature Corpus work: ee5e9ce9-fbc9-5e92-a460-c039c6ba2622
DOI: 10.1101/2021.05.17.444559

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