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Article

Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.

Nature - 26 Feb 2009

Luan Bing, Zhao Jian, Wu Haiya, Duan Baoyu, Shu Guangwen, Wang Xiaoying, Li Dangsheng, Jia Weiping, Kang Jiuhong, Pei Gang

Abstract excerpt

Insulin resistance, a hallmark of type 2 diabetes, is a defect of insulin in stimulating insulin receptor signalling, which has become one of the most serious public health threats. Upon stimulation by insulin, insulin receptor recruits and phosphorylates insulin receptor substrate proteins, leading to activation of the phosphatidylinositol-3-OH kinase (PI(3)K)-Akt pathway. Activated Akt phosphorylates downstream...

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Identifiers

PMID: 19122674
DOI: 10.1038/nature07617

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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