Article

Mechanisms involved in follistatin-induced hypertrophy and increased insulin action in skeletal muscle

2019-03-05

Abstract excerpt

<h4>Background</h4> Skeletal muscle wasting is often associated with insulin resistance. A major regulator of muscle mass is the transforming growth factor β (TGF-β) superfamily, including activin A, which causes atrophy. TGF-β superfamily ligands also negatively regulate insulin-sensitive proteins, but whether this pathway contributes to insulin action remains to be determined. <h4>Methods</h4> To elucidate if...

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Literature Corpus work: b840de1a-34a8-519f-bcbf-c19ee1d14ada
DOI: 10.1101/568097

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