Article

Regulatory Networks Shaping Human Tumor-Associated Macrophages In Vivo Identify MAFB as a Key Transcriptional Driver

2026-01-19

Abstract excerpt

<title>Abstract</title> <p>Tumor-associated macrophages (TAMs) are central drivers of resistance to conventional and immune-based therapies. Recent single-cell studies have uncovered an unexpected heterogeneity of macrophage states in human cancers, moving beyond the simplistic “M1–M2” paradigm. However, progress in understanding human TAM biology has been hampered by the lack of physiologically relevant in vivo...

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Literature Corpus work: 07d821cb-850e-5cda-9aa0-b81bcb1365b4
DOI: 10.21203/rs.3.rs-8562817/v1

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