Article

Telomeric DNA breaks in human induced pluripotent stem cells trigger ATR-mediated arrest and telomerase-independent telomere length maintenance

2023-01-21

Abstract excerpt

Although mechanisms of telomere protection are well-defined in differentiated cells, it is poorly understood how stem cells sense and respond to telomere dysfunction. Recent efforts have characterized the DNA damage response (DDR) following progressive telomere erosion in human pluripotent cells, yet the broader impact of telomeric double-strand breaks (DSBs) in these cells is poorly characterized. Here, we report...

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Literature Corpus work: 40c0a9ed-7dfb-5b8e-87b1-7c34b93f0ee2
DOI: 10.1101/2023.01.19.524780

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