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Article

Alternative Lengthening of Telomeres (ALT) in Tumors and Pluripotent Stem Cells

10 Dec 2019

Abstract excerpt

A telomere consists of repeated DNA sequences (TTAGGG)n as part of a nucleoprotein structure at the end of the linear chromosome, and their progressive shortening induces DNA damage response (DDR) that triggers cellular senescence. The telomere can be maintained by telomerase activity (TA) in the majority of cancer cells (particularly cancer stem cells) and pluripotent stem cells (PSCs), which exhibit unlimited...

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Share to Advanced biosensing and bioanalysis techniques
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PMID: 31835618
DOI: 10.3390/genes10121030

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