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A non-genetic switch triggers alternative telomere lengthening and cellular immortalization in ATRX deficient cells

20 Feb 2023

Abstract excerpt

Alternative Lengthening of Telomeres (ALT) is an aberrant DNA recombination pathway which grants replicative immortality to approximately 10% of all cancers. Despite this high prevalence of ALT in cancer, the mechanism and genetics by which cells activate this pathway remain incompletely understood. A major challenge in dissecting the events that initiate ALT is the extremely low frequency of ALT induction in...

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PMID: 36805596
DOI: 10.1038/s41467-023-36294-6

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