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Telomeres as hallmarks of iPSC aging: A review on telomere dynamics during stemness and cellular reprogramming

23 May 2025

Abstract excerpt

Telomeres, the protective ends of chromosome, are key to tissue repair and regeneration. Telomere shortening is linked to aging and age-related disorders, while excessive telomerase activity may support tissue regeneration or transformation. Some of the functions of telomeres and telomerase may be mediated by its important role in the process of stemness. Active telomerase, and subsequent telomerase-dependent...

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PMID: 40414363
DOI: 10.1016/j.arr.2025.102773

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