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ATR blocks telomerase from converting DNA breaks into telomeres

15 Feb 2024

Abstract excerpt

Telomerase, the enzyme that maintains telomeres at natural chromosome ends, should be repressed at double-strand breaks (DSBs), where neotelomere formation can cause terminal truncations. We developed an assay to detect neotelomere formation at Cas9- or I-SceI-induced DSBs in human cells. Telomerase added telomeric repeats to DSBs, leading to interstitial telomeric repeat insertions or the formation of functional...

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PMID: 38359122
DOI: 10.1126/science.adg3224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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