Article

The E2F4 transcriptional repressor is a key mechanistic regulator of colon cancer resistance to <i>irinotecan</i> (CPT-11)

2025-01-24

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background: </h4> Colorectal carcinomas (CRCs) are seldom eradicated by cytotoxic chemotherapy. Cancer cells with stem-like functional properties, often referred to as “cancer stem cells” (CSCs), display preferential resistance to several anti-tumor agents used in cancer chemotherapy, but the molecular mechanisms underpinning their selective survival remain only partially understood. <h4>M...

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Literature Corpus work: c6bc8d1c-fa2f-586b-8d30-b3d3d5fc1375
DOI: 10.1101/2025.01.22.633435

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