Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

M. tuberculosis CRISPR/Cas proteins are secreted virulence factors that trigger cellular immune responses

9 Dec 2021

Abstract excerpt

The role of prokaryotic CRISPR/Cas system proteins as a defensive shield against invasive nucleic acids has been studied extensively. Non-canonical roles in pathogenesis involving intracellular targeting of certain virulence-associated endogenous mRNA have also been reported for some Type I and Type II CRISPR/Cas proteins, but no such roles have yet been established for Type III system proteins. Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Cytomegalovirus and herpesvirus research
Share to Tuberculosis Research and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34886764
DOI: 10.1080/21505594.2021.2007621

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

M. tuberculosis CRISPR/Cas proteins are secreted virulence factors that trigger cellular immune responsesPMID 34886764Read ↗

The future of CRISPR in Mycobacterium tuberculosis infectionSemantic proximity Read ↗

Reprogramming the endogenous type III-A CRISPR-Cas system for genome editing, RNA interference and CRISPRi screening in <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Identification of Mycobacterium tuberculosis intracellular survival-related virulence factors via CRISPR-based eukaryotic-like secretory protein mutant library screenSemantic proximity Read ↗

Utilization of CRISPR interference to investigate the contribution of genes to pathogenesis in a macrophage model of Mycobacterium tuberculosis infectionSemantic proximity Read ↗

The effect of Mycobacterium tuberculosis CRISPR-associated Cas2 (Rv2816c) on stress response genes expression, morphology and macrophage survival of Mycobacterium smegmatis.Semantic proximity Read ↗

Diversity of CRISPR-Cas immune systems and molecular machines.Semantic proximity Read ↗

Cyclic oligoadenylate signalling mediates <i>Mycobacterium tuberculosis</i> CRISPR defenceSemantic proximity Read ↗

Development and clinical evaluation of a CRISPR/Cas13a-based diagnostic test to detect Mycobacterium tuberculosis in clinical specimensSemantic proximity Read ↗

Type I CRISPR-Cas targets endogenous genes and regulates virulence to evade mammalian host immunitySemantic proximity Read ↗

Reprogramming Mycobacterium Tuberculosis CRISPR System for Gene Editing and Genome-Wide RNA Interference ScreeningSemantic proximity Read ↗

ERA-CRISPR/Cas12a system: a rapid, highly sensitive and specific assay for Mycobacterium tuberculosisSemantic proximity Read ↗

Rapid and sensitive diagnosis of live Mycobacterium tuberculosis using clustered regularly interspaced short palindromic repeat‐Cas13a point‐of‐care RNA testingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.