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Structural insights into target detection by the <i>S. marcescens</i> type III CRISPR complex and its deployment in SNP identification

2026-03-31

Abstract excerpt

Type III CRISPR systems utilize a complex containing Cas10, additional Cas proteins and a crRNA to detect foreign transcripts. Upon detection, Cas10 synthesizes cyclic oligoadenylates (cOA), signaling molecules that coordinate interference by stimulating downstream enzymes with DNase, RNase, protease or other activities. Type III systems are among the most abundant CRISPR systems in prokaryotes and understanding t...

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Literature Corpus work
38b1b375-9616-5cb1-9428-39bfcb8d7ba6
DOI
10.64898/2026.03.30.715313
Open publication

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Structural insights into target detection by the <i>S. marcescens</i> type III CRISPR complex and its deployment in SNP identificationDOI 10.64898/2026.03.30.715313
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