Article

SCOPE: Flexible targeting and stringent CARF activation enables type III CRISPR-Cas diagnostics

2021-02-01

Abstract excerpt

<h4>Summary</h4> Characteristic properties of type III CRISPR-Cas systems include recognition of target RNA (rather than DNA) and the subsequent induction of a multifaceted immune response. This involves sequence-specific cleavage of a target RNA and production of cyclic oligoadenylate (cOA) second messenger molecules that may trigger dormancy or cell death. In this study, we discovered that a largely exposed see...

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Literature Corpus work: 4ecb0309-732e-5981-810f-9c0f95ca8ff6
DOI: 10.1101/2021.02.01.429135

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