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Article

Structural basis of cyclic oligoadenylate degradation by ancillary Type III CRISPR-Cas ring nucleases.

Nucleic acids research - 2 Dec 2021

Molina Rafael, Jensen Anne Louise Grøn, Marchena-Hurtado Javier, López-Méndez Blanca, Stella Stefano, Montoya Guillermo

Abstract excerpt

Type III CRISPR-Cas effector systems detect foreign RNA triggering DNA and RNA cleavage and synthesizing cyclic oligoadenylate molecules (cA) in their Cas10 subunit. cAs act as a second messenger activating auxiliary nucleases, leading to an indiscriminate RNA degradation that can end in cell dormancy or death. Standalone ring nucleases are CRISPR ancillary proteins which downregulate the strong immune response...

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Identifiers

PMID: 34850143
DOI: 10.1093/nar/gkab1130
PMCID: PMC8643638

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