Article
Synthetic lethality across normal tissues is strongly associated with cancer risk, onset, and tumor suppressor specificity
2019-10-25
Abstract excerpt
Various characteristics of cancers exhibit tissue-specificity, including lifetime cancer risk, onset age and cancer driver genes. Previously, the large variation in cancer risk across human tissues was found to strongly correlate with the number of stem cell divisions and abnormal DNA methylation levels occurring in them. Here we study the role of another potentially important factor, synthetic lethality, in cance...
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Identifiers and source
- Literature Corpus work
- e055c169-1a87-5422-919b-e6ec8b034de4
- DOI
- 10.1101/818922