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Article

Greater motor progression in patients with Parkinson disease who carry LRRK2 risk variants.

Neurology - 22 Sept 2015

Oosterveld Linda P, Allen John C, Ng Ebonne Y L, Seah Soo-Hoon, Tay Kay-Yaw, Au Wing-Lok, Tan Eng-King, Tan Louis C S

Abstract excerpt

OBJECTIVES: In a longitudinal follow-up study, we compared the clinical features and motor progression of patients with Parkinson disease (PD) who are carriers of the leucine-rich repeat kinase 2 (LRRK2) gene risk variants with patients who are noncarriers. METHODS: We prospectively evaluated a cohort of patients with PD for their clinical characteristics, disease severity, and LRRK2 genotype. Carriers of risk...

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Identifiers

PMID: 26311745
DOI: 10.1212/WNL.0000000000001953

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