Article
Parkinson's disease associated with LRRK2-R1441C mutation: Characterization and comparison with other LRRK2 mutations.
Journal of Parkinson's disease - 1 Aug 2025
Hadad Rafi, Alcalay Roy N, Senderova Inna, Nassar Maria, Milicic Andjelika, Peretz Judith Aharon, Allen Isabel Elaine, Ben-Hayun Rachel, Chasnyk Natalia, Morani Ilham, Elkoshi Nadav, Valcour Victor, Schlesinger Ilana
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene associate with familial and sporadic Parkinson's disease (PD). While various LRRK2 allelic variants have been studied, characteristics of R1441C carriers remain underexplored. We compared PD patients carrying the R1441C mutation (90% Isra...
Topics
- Aged
- Female
- Humans
- Male
- Middle Aged
- Arabs
- Jews
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mutation
- Parkinson Disease
- European People