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Article

Parkinson's disease associated with LRRK2-R1441C mutation: Characterization and comparison with other LRRK2 mutations.

Journal of Parkinson's disease - 1 Aug 2025

Hadad Rafi, Alcalay Roy N, Senderova Inna, Nassar Maria, Milicic Andjelika, Peretz Judith Aharon, Allen Isabel Elaine, Ben-Hayun Rachel, Chasnyk Natalia, Morani Ilham, Elkoshi Nadav, Valcour Victor, Schlesinger Ilana

Abstract excerpt

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene associate with familial and sporadic Parkinson's disease (PD). While various LRRK2 allelic variants have been studied, characteristics of R1441C carriers remain underexplored. We compared PD patients carrying the R1441C mutation (90% Israeli Arabs) to those carrying the G2019S (70% Ashkenazi Jews) and R1441G (42% Basque) variants. R1441C carriers...

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Identifiers

PMID: 40611668
DOI: 10.1177/1877718X251354986
PMCID: PMC13347503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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