Harnessing evolutionary fitness in <i>Plasmodium falciparum</i> for drug discovery and suppressing resistance

Abstract excerpt

Drug resistance emerges in an ecological context where fitness costs restrict the diversity of escape pathways. These pathways are targets for drug discovery, and here we demonstrate that we can identify small-molecule inhibitors that differentially target resistant parasites. Combining wild-type and mutant-type inhibitors may prevent the emergence of competitively viable resistance. We tested this hypothesis...

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