A broad analysis of resistance development in the malaria parasite.

doi:10.1038/ncomms11901

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Article

A broad analysis of resistance development in the malaria parasite.

Nature communications - 15 Jun 2016

Corey Victoria C, Lukens Amanda K, Istvan Eva S, Lee Marcus C S, Franco Virginia, Magistrado Pamela, Coburn-Flynn Olivia, Sakata-Kato Tomoyo, Fuchs Olivia, Gnädig Nina F, Goldgof Greg, Linares Maria, Gomez-Lorenzo Maria G, De Cózar Cristina, Lafuente-Monasterio Maria Jose, Prats Sara, Meister Stephan, Tanaseichuk Olga, Wree Melanie, Zhou Yingyao, Willis Paul A, Gamo Francisco-Javier, Goldberg Daniel E, Fidock David A, Wirth Dyann F, Winzeler Elizabeth A

Abstract excerpt

Microbial resistance to chemotherapy has caused countless deaths where malaria is endemic. Chemotherapy may fail either due to pre-existing resistance or evolution of drug-resistant parasites. Here we use a diverse set of antimalarial compounds to investigate the acquisition of drug resistance and the degree of cross-resistance against common resistance alleles. We assess cross-resistance using a set of 15...

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PMID: 27301419
DOI: 10.1038/ncomms11901
PMCID: PMC4912613

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