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Article

In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model.

Science translational medicine - 4 Dec 2019

Mandt Rebecca E K, Lafuente-Monasterio Maria Jose, Sakata-Kato Tomoyo, Luth Madeline R, Segura Delfina, Pablos-Tanarro Alba, Viera Sara, Magan Noemi, Ottilie Sabine, Winzeler Elizabeth A, Lukens Amanda K, Gamo Francisco Javier, Wirth Dyann F

Abstract excerpt

Resistance has developed in Plasmodium malaria parasites to every antimalarial drug in clinical use, prompting the need to characterize the pathways mediating resistance. Here, we report a framework for assessing development of resistance of Plasmodium falciparum to new antimalarial therapeutics. We investigated development of resistance by P. falciparum to the dihydroorotate dehydrogenase (DHODH) inhibitors...

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Identifiers

PMID: 31801884
DOI: 10.1126/scitranslmed.aav1636
PMCID: PMC7444640

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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