Article

TGF-β-pathway-based polygenic risk score modifies the association between red meat intake and colorectal cancer risk: Application of a novel pathway-based PRS method

2025-06-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Red and/or processed meat are established colorectal cancer (CRC) risk factors. Genome-wide association studies (GWAS) have reported over 200 variants associated with CRC risk. We used functional annotation data to identify subsets of variants within known pathways to construct pathway-based Polygenic Risk Scores (pPRS) to assess interactions with meat intake. <h4>Methods</h...

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Literature Corpus work: 401b0b18-b9b4-580e-9c96-6563319fb069
DOI: 10.1101/2025.06.13.25329599

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