Article
TGF-β Pathway-Based Polygenic Risk Score Modifies the Association between Red Meat Intake and Colorectal Cancer Risk: Application of a Novel Pathway-Based PRS Method.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 2 Jun 2026
Sanchez Mendez Joel, Queme Bryan, Fu Yubo, Morrison John L, Lewinger Juan Pablo, Kawaguchi Eric S, Mi Huaiyu, Obón-Santacana Mireia, Moratalla-Navarro Ferran, Martín Vicente, Moreno Victor, Qu Conghui, Huyghe Jeroen R, Newcomb Polly A, Phipps Amanda I, Thomas Claire E, Conti David V, Wang Jun, Platz Elizabeth A, Visvanathan Kala, Keku Temitope O, Newton Christina C, Um Caroline Y, Kundaje Anshul, Gunter Marc J, Dimou Niki, Papadimitriou Nikos, van Duijnhoven Fränzel J B, Männistö Satu, Rennert Gad, Wolk Alicja, Hoffmeister Michael, Brenner Hermann, Tian Yu, Le Marchand Loïc, Bouras Emmanouil, Tsilidis Konstantinos K, Bishop D Timothy, Maclnnis Robert J, Buchanan Daniel D, Ulrich Cornelia M, Peoples Anita R, Pellatt Andrew, Li Li, Devall Matthew A, Albanes Demetrius, Berndt Sonja I, Gruber Stephen B, Ruiz-Narvaez Edward, Song Mingyang, Drew David A, Chan Andrew T, Giannakis Marios, Hsu Li, Peters Ulrike, Stern Mariana C, Gauderman W James
Abstract excerpt
BACKGROUND: Red meat and/or processed meat are established colorectal cancer risk factors. Genome-wide association studies (GWAS) have reported more than 200 variants associated with colorectal cancer risk. We used functional annotation data to identify subsets of variants within known pathways to construct pathway-based polygenic risk scores (pPRS) to assess interactions with meat intake. METHODS: A pooled...
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