Article

Pathway Polygenic Risk Scores (pPRS) for the Analysis of Gene-environment Interaction

2024-12-20

Abstract excerpt

A polygenic risk score (PRS) is used to quantify the combined disease risk of many genetic variants. For complex human traits there is interest in determining whether the PRS modifies, i.e. interacts with, important environmental (E) risk factors. Detection of a PRS by environment (PRS x E) interaction may provide clues to underlying biology and can be useful in developing targeted prevention strategies for modifi...

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Literature Corpus work: 72136b83-c8de-5ba7-af9c-5eb605c793e6
DOI: 10.1101/2024.12.16.628610

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