Article
Using gene-environment interactions to explore pathways for colorectal cancer risk.
EBioMedicine - 1 Nov 2025
Bouras Emmanouil, Yu Ren, Kim Andre E, Markozannes Georgios, Murphy Neil, Albanes Demetrius, Anderson Laura N, Barry Elizabeth L, Berndt Sonja I, Bishop D Timothy, Brenner Hermann, Burnett-Hartman Andrea, Campbell Peter T, Carreras-Torres Robert, Chan Andrew T, Cheng Iona, Devall Matthew A, Diez-Obrero Virginia, Dimou Niki, Drew David A, Gruber Stephen B, Gsur Andrea, Hoffmeister Michael, Hsu Li, Huyghe Jeroen R, Kawaguchi Eric, Keku Temitope O, Kundaje Anshul, Küry Sébastien, Le Marchand Loïc, Lewinger Juan Pablo, Li Li, Lynch Brigid M, Moreno Victor, Morrison John L, Newton Christina C, Obón-Santacana Mireia, Palmer Julie R, Papadimitriou Nikos, Pellatt Andrew J, Peoples Anita R, Pharoah Paul D P, Platz Elizabeth A, Qu Conghui, Ruiz-Narvaez Edward, Mendez Joel Sanchez, Schoen Robert E, Stern Mariana C, Thomas Claire E, Tian Yu, Um Caroline Y, Visvanathan Kala, Vodicka Pavel, Vymetalkova Veronika, White Emily, Wolk Alicja, Woods Michael O, Wu Anna H, Gunter Marc J, Gauderman W James, Peters Ulrike, Evangelou Marina, Tsilidis Konstantinos K
Abstract excerpt
BACKGROUND: Colorectal cancer (CRC) is a significant public health concern, highlighting the critical need for identifying novel intervention targets for its prevention. METHODS: We conducted genome-wide interaction analyses for 15 exposures with established or putative CRC risk [body mass index (BMI), height, physical activity, smoking, type 2 diabetes, use of menopausal hormone therapy, non-steroidal...
Read the complete abstract on PubMed