Article
Pathway analysis of genome-wide association study and transcriptome data highlights new biological pathways in colorectal cancer.
Molecular genetics and genomics : MGG - 1 Apr 2015
Quan Baoku, Qi Xingsi, Yu Zhihui, Jiang Yongshuai, Liao Mingzhi, Wang Guangyu, Feng Rennan, Zhang Liangcai, Chen Zugen, Jiang Qinghua, Liu Guiyou
Abstract excerpt
Colorectal cancer (CRC) is a common malignancy that meets the definition of a complex disease. Genome-wide association study (GWAS) has identified several loci of weak predictive value in CRC, however, these do not fully explain the occurrence risk. Recently, gene set analysis has allowed enhanced interpretation of GWAS data in CRC, identifying a number of metabolic pathways as important for disease pathogenesis....
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