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Article

Pathway polygenic risk scores (pPRS) for the analysis of gene-environment interaction.

PLoS genetics - 1 Aug 2025

Gauderman W James, Fu Yubo, Queme Bryan, Kawaguchi Eric, Wang Yinqiao, Morrison John, Brenner Hermann, Chan Andrew, Gruber Stephen B, Keku Temitope, Li Li, Moreno Victor, Pellatt Andrew J, Peters Ulrike, Samadder N Jewel, Schmit Stephanie L, Ulrich Cornelia M, Um Caroline, Wu Anna, Lewinger Juan Pablo, Drew David A, Mi Huaiyu

Abstract excerpt

A polygenic risk score (PRS) is used to quantify the combined disease risk of many genetic variants. For complex human traits there is interest in determining whether the PRS modifies, i.e. interacts with, important environmental (E) risk factors. Detection of a PRS by environment (PRS x E) interaction may provide clues to underlying biology and can be useful in developing targeted prevention strategies for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40763299
DOI: 10.1371/journal.pgen.1011543
PMCID: PMC12352875

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