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Article

Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids

23 Feb 2019

Abstract excerpt

Recent advances in generating three-dimensional (3D) organoid systems from stem cells offer new possibilities for disease modeling and drug screening because organoids can recapitulate aspects of in vivo architecture and physiology. In this study, we generate isogenic 3D midbrain organoids with or without a Parkinson's disease-associated LRRK2 G2019S mutation to study the pathogenic mechanisms associated with...

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PMID: 30799274
DOI: 10.1016/j.stemcr.2019.01.020

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