Article

A human multilineage gut organoid model for Parkinson disease

2025-12-18

Abstract excerpt

<h4>Summary</h4> Emerging evidence links gut dysfunction to Parkinson disease (PD) pathogenesis, yet human models to study gut-related mechanisms are lacking. We developed a human intestinal organoid model incorporating PD-relevant cell types. Using control and PD patient-derived pluripotent stem cells, we generated intestinal epithelial organoids and vagal neural crest cells, then co-cultured them into assembloi...

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Literature Corpus work: 19c53715-91e5-5cc7-acfa-67d6c544ff57
DOI: 10.64898/2025.12.16.694313

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