Back to search

Article

Sleep and Alzheimer’s Disease: Shared Genetic Risk Factors, Drug Targets, Molecular Mechanisms, and Causal Effects

2021-09-09

Abstract excerpt

<title>Abstract</title> <p>Background: Alzheimer’s disease (AD) was associated with sleep-related phenotypes (SRPs). Whether they share common genetic etiology remains largely unknown. We explored the shared genetics and causality between AD and SRPs by using high-definition likelihood (HDL), cross phenotype association study (CPASSOC), transcriptome wide association study (TWAS), and bidirectional Mendelian rand...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3fbc8f9c-3d5a-5619-8220-52a28086e90f
DOI
10.21203/rs.3.rs-853181/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Sleep and Alzheimer’s Disease: Shared Genetic Risk Factors, Drug Targets, Molecular Mechanisms, and Causal EffectsDOI 10.21203/rs.3.rs-853181/v1
Sleep duration, genetic susceptibility, and Alzheimer's disease: a longitudinal UK Biobank-based study.Semantic proximity
Alzheimer's Disease Investigated via Gene-Environment Interactions, Biochemical Pathways, Cellular Processes, and Disease Phenotype VariabilitySemantic proximity
Golgi apparatus, endoplasmic reticulum and mitochondrial function implicated in Alzheimer's disease through polygenic risk and RNA sequencing.Semantic proximity
Lipid associated polygenic enrichment in Alzheimer’s diseaseSemantic proximity
Causal association of lifestyle factors, clinical features in the risk of sleep disorders: Based on mendelian randomization analysisSemantic proximity
Analysis of Alzheimer’s disease Polygenic Risk Scores using RNA-sequencing provides further novel biological pathwaysSemantic proximity
Exome-Wide Association Study Identified Clusters of Pleiotropic Genetic Associations with Alzheimer's Disease and Thirteen Cardiovascular Traits.Semantic proximity
Sleep disturbances as risk factors for neurodegeneration later in lifeSemantic proximity
Association of Polygenic Risk Score for 5 Diseases With Alzheimer Disease Progression, Biomarkers, and Amyloid Deposition.Semantic proximity
The causes and consequences of Alzheimer’s disease: phenome-wide evidence from Mendelian randomizationSemantic proximity
Investigating Genetic Overlap between Alzheimer's Disease, Lipids, and Coronary Artery Disease: A Large-Scale Genome-Wide Cross Trait Analysis.Semantic proximity
Integrative SMR prioritizes oxidative stress-related regulatory genes for Alzheimer's disease with brain-tissue validation.Semantic proximity
Select a neighboring publication to make it the new centre.