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Article

Integrative SMR prioritizes oxidative stress-related regulatory genes for Alzheimer's disease with brain-tissue validation.

The journal of prevention of Alzheimer's disease - 1 May 2026

Wu Liu, Dong Yu-Ting, Mu Xin, Luo Xiao, Chen Ze-Jun

Abstract excerpt

Oxidative stress (OS) plays a critical role in the pathogenesis of Alzheimer's disease (AD), yet its genetic and epigenetic regulatory mechanisms remain unclear. In this study, we applied a three-step summary-based Mendelian randomization (SMR) framework to integrate Alzheimer's disease (AD) GWAS summary statistics with peripheral-blood eQTL and mQTL datasets, and further evaluated brain-tissue relevance using...

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Source

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Identifiers

PMID: 41844011
DOI: 10.1016/j.tjpad.2026.100535
PMCID: PMC13014940

Genes

ABCA1
APP
CRLS1
CYP2E1
GPX1
KEAP1
PRDX5
PRKAA1
SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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