Article

ASCL1 primes medullary thymic epithelial cell programs required for central tolerance

2025-08-07

Abstract excerpt

Immunological self-tolerance depends on medullary thymic epithelial cells (mTECs), which express a broad repertoire of self-antigens to support negative selection of autoreactive T cells and the development of regulatory T cells. Although the autoimmune regulator AIRE is essential for this process, additional factors are required to establish the full mTEC gene expression program. Because thymoma is frequently ass...

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Literature Corpus work: 7e4704c4-ab3e-5680-8bca-4138a7bf6790
DOI: 10.1101/2025.08.06.668799

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