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Article

Mutations and mechanisms of WNT pathway tumour suppressors in cancer.

Nature reviews. Cancer - 1 Jan 2021

Bugter Jeroen M, Fenderico Nicola, Maurice Madelon M

Abstract excerpt

Mutation-induced activation of WNT-β-catenin signalling is a frequent driver event in human cancer. Sustained WNT-β-catenin pathway activation endows cancer cells with sustained self-renewing growth properties and is associated with therapy resistance. In healthy adult stem cells, WNT pathway activity is carefully controlled by core pathway tumour suppressors as well as negative feedback regulators. Gene...

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Identifiers

PMID: 33097916
DOI: 10.1038/s41568-020-00307-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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