Article
Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signaling.
Nature genetics - 1 Feb 2026
Krishna Anagha, Meynert Alison, Dolt Karamjit Singh, Kelder Martijn, Mesropian Agavni, Ewing Ailith, Brouwers Conny, Claassens Jill Wc, Linssen Margot M, Sheraz Shahida, Taylor Gillian Ca, Gautier Philippe, Ferrer-Vaquer Anna, Grimes Graeme, Becher Hannes, Silk Ryan, Gris-Oliver Albert, Pinyol Roser, Semple Colin A, Kendall Timothy J, Bird Thomas Graham, Hadjantonakis Anna-Katerina, Marsh Joseph A, Llovet Josep M, Hohenstein Peter, Wood Andrew J, Ozdemir Derya D
Abstract excerpt
CTNNB1, the gene encoding β-catenin, is a frequent target for oncogenic mutations activating the canonical Wnt signaling pathway, typically through missense mutations within a degron hotspot motif in exon 3. Here, we combine saturation genome editing with a fluorescent reporter assay to quantify signaling phenotypes for all 342 possible missense mutations in the mutation hotspot. Our data define the genetic...
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