Article

Mutational scanning reveals oncogenic <i>CTNNB1</i> mutations have diverse effects on signalling and clinical traits

2023-11-13

Abstract excerpt

CTNNB1 , the gene encoding β-catenin, is a frequent target for oncogenic mutations activating the canonical Wnt signalling pathway, typically via missense mutations within a degron hotspot motif in exon 3. Here, we combine saturation genome editing with a fluorescent reporter assay to quantify signalling phenotypes for all 342 missense mutations in the mutation hotspot, including 74 recurrent mutations reported in...

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Literature Corpus work: 659c9f7b-c581-520e-92ba-e8ef8d31194c
DOI: 10.1101/2023.11.09.566307

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