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Article

Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Aug 2008

Wang Xianshu, Goode Ellen L, Fredericksen Zachary S, Vierkant Robert A, Pankratz V Shane, Liu-Mares Wen, Rider David N, Vachon Celine M, Cerhan James R, Olson Janet E, Couch Fergus J

Abstract excerpt

Aberrant Wnt/beta-catenin signaling leading to nuclear accumulation of the oncogene product beta-catenin is observed in a wide spectrum of human malignancies. The destruction complex in the Wnt/beta-catenin pathway is critical for regulating the level of beta-catenin in the cytoplasm and in the nucleus. Here, we report a comprehensive study of the contribution of genetic variation in six genes encoding the...

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Source

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Identifiers

PMID: 18708403
DOI: 10.1158/1055-9965.EPI-08-0134
PMCID: PMC2771409

Genes

AXIN2
APC
AXIN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancer.PMID 18708403Read ↗

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