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Article

Specificity determinants of allosteric modulation in the neuronal nicotinic acetylcholine receptor: a fine line between inhibition and potentiation.

Molecular pharmacology - 1 Feb 2012

Cesa Laura C, Higgins Colin A, Sando Steven R, Kuo Dennis W, Levandoski Mark M

Abstract excerpt

We are interested in the allosteric modulation of neuronal nicotinic acetylcholine receptors (nAChRs). We have postulated that the anthelmintic morantel (Mor) positively modulates (potentiates) rat α3β2 receptors through a site located at the β(+)/α(-) interface that is homologous to the canonica...

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Source

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Identifiers

PMID: 22064677
DOI: 10.1124/mol.111.076059
PMCID: PMC3263947

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22064677-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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