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Article

Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site.

Proceedings of the National Academy of Sciences of the United States of America - 23 Sept 2008

Young Gareth T, Zwart Ruud, Walker Alison S, Sher Emanuele, Millar Neil S

Abstract excerpt

Positive allosteric modulators of alpha7 nicotinic acetylcholine receptors (nAChRs) have attracted considerable interest as potential tools for the treatment of neurological and psychiatric disorders such as Alzheimer's disease and schizophrenia. However, despite the potential therapeutic usefulness of these compounds, little is known about their mechanism of action. Here, we have examined two allosteric...

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Identifiers

PMID: 18791069
DOI: 10.1073/pnas.0804372105
PMCID: PMC2535569

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