Article
Clinically Observed Estrogen Receptor Alpha Mutations within the Ligand-Binding Domain Confer Distinguishable Phenotypes.
Oncology - 1 Jan 2018
Jia Shanhang, Miedel Mark T, Ngo Marilyn, Hessenius Ryan, Chen Ning, Wang Peilu, Bahreini Amir, Li Zheqi, Ding Zhijie, Shun Tong Ying, Zuckerman Daniel M, Taylor D Lansing, Puhalla Shannon L, Lee Adrian V, Oesterreich Steffi, Stern Andrew M
Abstract excerpt
OBJECTIVE: Twenty to fifty percent of estrogen receptor-positive (ER+) metastatic breast cancers express mutations within the ER ligand-binding domain. While most studies focused on the constitutive ER signaling activity commonly engendered by these mutations selected during estrogen deprivation therapy, our study was aimed at investigating distinctive phenotypes conferred by different mutations within this...
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