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Article

Estrogen receptor mutations and functional consequences for breast cancer.

Trends in endocrinology and metabolism: TEM - 1 Sept 2015

Thomas Christoforos, Gustafsson Jan-Åke

Abstract excerpt

A significant number of estrogen receptor α (ERα)-positive breast tumors develop resistance to endocrine therapy and recur with metastatic disease. Several mechanisms of endocrine resistance have been proposed, including genetic alterations that lead to ERs with altered protein sequence. By altering the conformation of the protein and increasing the interaction with coactivators, point mutations in ESR1, the gene...

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PMID: 26183887
DOI: 10.1016/j.tem.2015.06.007

Genes

ESR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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