Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Genetic Bottleneck of Mitochondrial DNA During Human Lymphocyte Development.

Molecular biology and evolution - 3 May 2022

Tang Zhongjie, Lu Zhaolian, Chen Baizhen, Zhang Weixing, Chang Howard Y, Hu Zheng, Xu Jin

Abstract excerpt

Mitochondria are essential organelles in eukaryotic cells that provide critical support for energetic and metabolic homeostasis. Although the elimination of pathogenic mitochondrial DNA (mtDNA) mutations in somatic cells has been observed, the mechanisms to maintain proper functions despite their mtDNA mutation load are poorly understood. In this study, we analyzed somatic mtDNA mutations in more than 30,000...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bayes Theorem
Share to DNA, Mitochondrial
Share to Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondria

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 35482398
DOI: 10.1093/molbev/msac090
PMCID: PMC9113143

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Genetic Bottleneck of Mitochondrial DNA During Human Lymphocyte Development.PMID 35482398Read ↗

A genetic bottleneck of mitochondrial DNA during human lymphocyte developmentSemantic proximity Read ↗

Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells.Semantic proximity Read ↗

T cell differentiation drives the negative selection of pathogenic mtDNA variantsSemantic proximity Read ↗

Single-cell multi-omics reveals dynamics of purifying selection of pathogenic mitochondrial DNA across human immune cellsSemantic proximity Read ↗

T cell differentiation drives the negative selection of pathogenic mitochondrial DNA variantsSemantic proximity Read ↗

Mitochondrial DNA mosaicism in human normal somatic cellsSemantic proximity Read ↗

Clonal expansion dictates the efficacy of mitochondrial lineage tracing in single cellsSemantic proximity Read ↗

Mitochondrial variant enrichment from high-throughput single-cell RNA sequencing resolves clonal populations.Semantic proximity Read ↗

Mitochondrial variant enrichment from high-throughput single-cell RNA-seq resolves clonal populationsSemantic proximity Read ↗

Mitochondrial DNA mosaicism in normal human somatic cells.Semantic proximity Read ↗

Deleterious heteroplasmic mitochondrial mutations increase risk of overall and cancer-specific mortalitySemantic proximity Read ↗

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.