Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Developmental disruption of the mitochondrial fission gene drp-1 extends the longevity of daf-2 insulin/IGF-1 receptor mutant.

GeroScience - 1 Feb 2025

Traa Annika, Tamez González Aura A, Van Raamsdonk Jeremy M

Abstract excerpt

The dynamic nature of the mitochondrial network is regulated by mitochondrial fission and fusion, allowing for re-organization of mitochondria to adapt to the cell's ever-changing needs. As organisms age, mitochondrial fission and fusion become dysregulated and mitochondrial networks become increasingly fragmented. Modulation of mitochondrial dynamics has been shown to affect longevity in fungi, yeast, Drosophila...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dynamins

Share to Longevity

Share to Mitochondria

Share to Mitochondrial Dynamics

Share to Receptor, IGF Type 1

Share to Receptor, Insulin

Source

Open in PubMed Open full text

Identifiers

PMID: 39028454
DOI: 10.1007/s11357-024-01276-z
PMCID: PMC11872967

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Developmental disruption of the mitochondrial fission gene drp-1 extends the longevity of daf-2 insulin/IGF-1 receptor mutant.PMID 39028454Read ↗

The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity.Semantic proximity Read ↗

Raptor and Drp1 Function Synthetically to Control Hypoxic Death and the Mitochondrial Network in Caenorhabditis elegans.Semantic proximity Read ↗

DRP-1-mediated apoptosis induces muscle degeneration in dystrophin mutants.Semantic proximity Read ↗

Overexpression of mitochondrial fusion genes enhances resilience and extends longevitySemantic proximity Read ↗

Mitochondrial redox homeostasis links organellar stress surveillance to germline and somatic integrity in Caenorhabditis elegans.Semantic proximity Read ↗

Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogasterSemantic proximity Read ↗

Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson's disease models.Semantic proximity Read ↗

The paradox of mitochondrial dysfunction and extended longevity.Semantic proximity Read ↗

Autophagy compensates for defects in mitochondrial dynamicsSemantic proximity Read ↗

Mitochondrial redox homeostasis links organellar stress surveillance to germline and somatic integrity in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Coupling mitogenesis and mitophagy for longevitySemantic proximity Read ↗

C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.