Article

Rational design of structure-based vaccines targeting misfolded alpha-synuclein conformers of Parkinson’s disease and related disorders

2023-06-30

Abstract excerpt

<h4>Background</h4> Synucleinopathies, including Parkinson’s disease, multiple system atrophy, and dementia with Lewy bodies, are neurodegenerative disorders caused by the accumulation of misfolded alpha-synuclein protein. Developing effective vaccines against synucleinopathies has been challenging due to the difficulty of stimulating an immune-specific response against alpha-synuclein, conferring neuroprotection...

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Literature Corpus work: 9f9faa91-94d4-51ae-87c9-57adfe2b6527
DOI: 10.1101/2023.06.30.547254

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