Article

Computationally engineered cyclic peptides reduce prion levels <i>in vitro</i>

2026-07-07

Abstract excerpt

Prion diseases are neurodegenerative disorders associated with the structural conversion of the cellular prion protein (PrP c ) into its misfolded infectious isoform (PrP Sc ). Despite substantial efforts, no disease-modifying therapy or cure is currently available. Here, we present an integrated computational-experimental pipeline for the rational design of cyclic peptides targeting PrP c to inhibit its pathog...

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Literature Corpus work: 4b4e24eb-da48-51af-a5f2-be73ee141357
DOI: 10.64898/2026.07.03.736251

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