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Alzheimer disease β-amyloid pathology accelerates age-related hearing loss: evidence from <i>App</i> <sup>NL-F</sup> “knock-in” mice

2026-05-28

Abstract excerpt

Age-related hearing loss (ARHL) is a main acquired risk factor for dementia, including Alzheimer disease (AD), but links are unknown. We are using a mouse model with traits of both aging pathologies to test mechanistic interactions. The “knock-in” App NL-F mouse reproduces β-amyloid pathology in brain regions homologous to those involved in human AD. Because it was generated from the C57BL/6J mouse, it expresses...

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Literature Corpus work: 96e59ed1-10fc-5fc4-bf19-49088c63c2a4
DOI: 10.64898/2026.05.25.727095

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